Das Leibniz-Institut zur Analyse des Biodiversitätswandels

ist ein Forschungsmuseum der Leibniz Gemeinschaft

The European Reference Genome Atlas: piloting a decentralised approach to equitable biodiversity genomics

Vollständiger Titel: 
The European Reference Genome Atlas: piloting a decentralised approach to equitable biodiversity genomics
ZFMK-Autorinnen / ZFMK-Autoren: 
Publiziert in: 
Elektronische Publikation
DOI Name: 
genomics, biodiversity, ERGA
Bibliographische Angaben: 
McCartney AM, Formenti G, Mouton A, DePanis D, Marins LS, Leitao HG, Diedericks G, Kirangwa J, Morselli M, Salces J, Escudero N, Iannucci A, Natali C, Svardal H, Fernandez R, DePooter T, Joris G, Strazisar M, Wood J, Herron KE, Seehausen O, Watts PC, Shaw F, Davey RP, Minotto A, Fernandez Gonzalez JM, Böhne A, Alegria C, Alioto T, Alves PC, Amorim IR, Aury JM, Backstrom N, Baldrian P, Ballarin L, Baltrunaite L, Barta E, BedHom B, Belser C, Bergsten J, Bertrand L, Bilandija H, Binzer-Panchal M, Bista I, Blaxter M, Borges PAV, Borges Dias G, Bosse M, Brown T, Bruggmann R, Buena-Atienza E, Burgin J, Buzan E, Casadei N, Chiara M, Chozas S, Ciampor Jr. F, Crottini A, Cruaud C, Cruz F, Dalen L, De Biase A, del Campo J, Delic T, Dennis AB, Derks MFL, Diroma MA, Djan M, Duprat S, Eleftheriadi K, Feulner PGD, Flot JF, Forni G, Fosso B, Fournier P, Fournier-Chambrillon C, Gabaldon T, Garg S, Gissi C, Giupponi L, Gomez-Garrido J, Gonzalez J, Grilo ML, Gruening B, Guerin T, Guiglielmoni N, Gut M, Haesler MP, Hahn C, Halpern B, Harrison P, Heintz J, Hindrikson M, Hoglund J, Howe K, Hughes G, Istace B, Cock MJ, Jancekovic F, Jonsson ZO, Joye-Dind S, Koskimaki JJ, Krystufek B, Kubacka J, Kuhl H, Kusza S, Labadie K, Lahteenaro M, Lantz H, Lavrinienko A, Leclere L, Lopes RJ, Madsen O, Magdelenat G, Magoga G, Manousaki T, Mappes T, Marques JP, Martinez Redondo GI, Maumus F, McCarthy SA, Megens HJ, Melo-Ferreira J, Mendes SL, Montagna M, Moreno J, Mosbech MB, Moura M, Musilova Z, Myers E, Nash WJ, Nater A, Nicholson P, Niell M, Nijland R, Noel B, Noren K, Oliveira PH, Olsen RA, Ometto L, Ossowski S, Palinauskas V, Palsson S, Panibe JP, Pauperio J, Pavlek M, Payen E, Pawlowska J, Pellicer J, Pesole G, Pimenta J, Pippel M, Pirttila AM, Poulakakis N, Rajan J, Rego RMC, Resendes R, Resl P, Riesgo A, Rodin-Morch P, Soares AER, Rodriguez Fernandes C, Romeiras MM, Roxo G, Ruber L, Jose Ruiz-Lopez M, Saarma U, Silva LP, Sim-Sim M, Soler L, Sousa VC, Sousa Santos C, Spada A, Stefanovic M, Steger V, Stiller J, Stock M, Struck TH, Sudasinghe H, Tapanainen R, Tellgren-Roth C, Trindade H, Tukalenko Y, Urso I, Vacherie B, Van Belleghem SM, van Oers K, Vargas-Chavez C, Velickovic N, Vella N, Vella A, Vernesi C, Vicente S, Villa S, Vinnere Pettersson O, Volckaert FAM, Voros J, Wincker P, Winkler S, Ciofi C, Waterhouse RM, Mazzoni CJ. (2024) The European Reference Genome Atlas: piloting a decentralised approach to equitable biodiversity genomics.BioRxiv 2023.09.25.559365. doi: 10.1101/2023.09.25.559365

A global genome database of all of Earth's species diversity could be a treasure trove of scientific discoveries. However, regardless of the major advances in genome sequencing technologies, only a tiny fraction of species have genomic information available. To contribute to a more complete planetary genomic database, scientists and institutions across the world have united under the Earth BioGenome Project (EBP), which plans to sequence and assemble high-quality reference genomes for all ~1.5 million recognized eukaryotic species through a stepwise phased approach. As the initiative transitions into Phase II, where 150,000 species are to be sequenced in just four years, worldwide participation in the project will be fundamental to success. As the European node of the EBP, the European Reference Genome Atlas (ERGA) seeks to implement a new decentralised, accessible, equitable and inclusive model for producing high-quality reference genomes, which will inform EBP as it scales. To embark on this mission, ERGA launched a Pilot Project to establish a network across Europe to develop and test the first infrastructure of its kind for the coordinated and distributed reference genome production on 98 European eukaryotic species from sample providers across 34 European countries. Here we outline the process and challenges faced during the development of a pilot infrastructure for the production of reference genome resources, and explore the effectiveness of this approach in terms of high-quality reference genome production, considering also equity and inclusion. The outcomes and lessons learned during this pilot provide a solid foundation for ERGA while offering key learnings to other transnational and national genomic resource projects.

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